Which process involves the arrival and movement of white blood cells to the injured tissue?

Which process involves the arrival and movement of white blood cells to the injured tissue?

• A. Leukocyte migration
• B. Phagocytosis
• C. Chemical mediation
• D. Metabolic changes

Answer: (A)

Leukocyte migration is the movement and arrival of white blood cells to injured tissue. In an inflammatory response, signals such as cytokines and chemokines released by damaged cells and pathogens create a chemical gradient and activate the endothelium. This causes white blood cells to slow down and roll along the vessel wall, adhere firmly via integrins, and then squeeze through the vessel wall (diapedesis) to reach the affected area. Once at the site, they follow the chemotactic cues to the exact location of injury to help with defense and cleanup. This process specifically describes recruitment and trafficking, whereas phagocytosis refers to the engulfment of particles after arrival, chemical mediation means the signaling molecules guiding the response, and metabolic changes are general cellular adjustments not unique to leukocyte movement.

Leukocyte migration is the movement and arrival of white blood cells to injured tissue. In an inflammatory response, signals such as cytokines and chemokines released by damaged cells and pathogens create a chemical gradient and activate the endothelium. This causes white blood cells to slow down and roll along the vessel wall, adhere firmly via integrins, and then squeeze through the vessel wall (diapedesis) to reach the affected area. Once at the site, they follow the chemotactic cues to the exact location of injury to help with defense and cleanup. This process specifically describes recruitment and trafficking, whereas phagocytosis refers to the engulfment of particles after arrival, chemical mediation means the signaling molecules guiding the response, and metabolic changes are general cellular adjustments not unique to leukocyte movement.